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No evidence suggests that he is, but you can safely say we won't see him again. The GTA III canon is over now and we're in the GTA IV era, and the graffiti in GTA IV certainly seems to suggest Rockstar has put all previous protagonists to bed. Whether or not any of them are really dead is up to the player to decide - though the fact he was born in 1949 would now put him in his 60s, so if he hasn't been murdered then the stress of running Vice City would've probably given him a heart attack.

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